Jiqiang Ling, PhD

  • Assistant Professor (Tenure-track), Microbiology and Molecular Genetics, UTHealth

Biography

I am currently a tenure-track assistant professor at The University of Texas Health Science Center at Houston. The long-term research goals of my laboratory are to understand the interplay between microbial stress responses, translational fidelity and bacterial pathogenesis. The expertise needed for the proposed work began to develop when I was a Ph.D. student at the Ohio State University, where I performed biochemical and biophysical studies of the translational quality control machinery. Mentored by Dr. Michael Ibba, I learned in vitro and in vivo techniques to study the protein synthesis machinery, including aminoacyl-tRNA synthetases (aaRSs), tRNAs, elongation factors, and the ribosome. My Ph.D. work resulted in nine peer-reviewed publications, including five first-author papers in Mol. Cell, Annu. Rev. Microbiol., Proc. Natl. Acad. Sci. USA, and RNA. In 2008, I joined Dr. Dieter Söll’s laboratory as a postdoctoral associate at Yale University, where I have gained new expertise in microbial stress responses and bacterial genetics. I demonstrated that oxidative stress causes protein mistranslation in bacteria, and also determined the first mistranslation-induced aggregated proteome (caused by aminoglycoside antibiotics that promote ribosomal decoding errors) using quantitative mass spectrometry. During my postdoctoral training, I published a total of 15 papers including eight first-author articles in Mol. Cell, Proc. Natl. Acad. Sci. USA, Nat. Chem. Biol., Nucleic Acids Res., J Biol. Chem., ChemBioChem, Nat. Rev. Microbiol., and three more corresponding-author papers in Nucleic Acids Res. and FEBS Lett. Since I started my own laboratory in 2013, we have combined genetic, biochemical, and systems biology tools to study the regulation and cellular responses of mistranslation. Some of this fully independent work from my laboratory was published in two original research articles. Recently, we have been collaborating with Dr. Michael Lorenz’s laboratory in our department to study Salmonella-macrophage interaction. We have also collaborated with Dr. Theresa Koehler’s laboratory (our department) to test how Bacillus responds to mistranslation. In addition, my group has been collaborating with human genetics and structural biology groups to study aminoacyl-tRNA synthetases and human neurological diseases, which has resulted in four publications and one more manuscript in preparation.

 

Education

B.S.
Biology, Fudan University (Shanghai, China)
Ph.D.
Biochemistry, The Ohio State University
Postdoctoral
Molecular Biophysics and Biochemistry, Yale University